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Individualized management strategies based on different subtypes of POTS would largely improve the curative effects of drugs for children with POTS, and further clinical investigation is still required to better understand the pathophysiology and treatment options. Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disease that predominantly affects children and adolescents. There is a great difference between children and adults in the diagnosis and treatment of POTS patients. POTS in children and adolescents is marked by chronic symptoms of orthostatic intolerance with a heart rate (HR) rise of ≥40 bpm, or heart rate exceeding 130 bpm for 6–12-years-old children and exceeding 125 bpm for those 13–18 years old without orthostatic hypotension, which is different from adult patients. The three major clinical forms of POTS include hypovolemic POTS, neuropathic POTS, and hyperadrenergic POTS; these are distinguished by their major mechanisms. The different subtypes of POTS in children and adolescents each have their own clinical characteristics and biomarkers. Based on these, we propose individualized treatment strategies. Individualized management strategies based on different subtypes of POTS would largely improve the curative effects of drugs for children with POTS. However, a further clinical investigation is still required to better understand the pathophysiology and treatment options.
Resource Library Standing Up To POTS
POTS pathophysiological subtypes
Postural Orthostatic Tachycardia Syndrome: JACC Focus Seminar
Postural Orthostatic Tachycardia Syndrome: Symptoms, Causes, and
Typical hemodynamic response of a healthy control (HC) during a
future unknown Bless hyperadrenergic pots Persecute Disability
Dysautonomia: Causes, Symptoms and Treatments - The Dysautonomia
The 3 Ws of Postural Orthostatic Tachycardia Syndrome (POTS)
Medication for POTS + Other Treatments That Work
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Dysautonomia Treatment & POTS Survival Kit: Lifestyle Medicine
Postural Orthostatic Tachycardia Syndrome (POTS)
Postural Orthostatic Tachycardia Syndrome in COVID-19
