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Environmental and genetic factors may modify or contribute to the phenotypic differences observed in multigenic and monogenic diseases, such as cystic fibrosis (CF). An analysis of modifier genes can be helpful for estimating patient prognosis and directing preventive care. The aim of this study is to determine the association between seven genetic variants of four modifier genes and CF by comparing their corresponding allelic and genotypic frequencies in CF patients (n = 81) and control subjects (n = 104). Genetic variants of MBL2 exon 1 (A, B, C and D), the IL-8 promoter (−251 A/T), the TNFα promoter (TNF1/TNF2), and SERPINA1 (PI*Z and PI*S) were tested in CF patients and control subjects from northeastern Mexico by PCR-RFLP. Results The TNF2 allele (P = 0.012, OR 3.43, 95% CI 1.25–9.38) was significantly associated with CF under the dominant and additive models but was not associated with CF under the recessive model. This association remained statistically significant after adjusting for multiple tests using the Bonferroni correction (P = 0.0482). The other tested variants and genotypes did not show any association with the disease. Conclusion An analysis of seven genetic variants of four modifier genes showed that one variant, the TNF2 allele, appears to be significantly associated with CF in Mexican patients.
Tumour necrosis factor α −308G→A polymorphism is not associated with response to TNFα blockers in Caucasian patients with rheumatoid arthritis: systematic review and meta-analysis
PDF) Frequency of S and Z alleles for alpha-1-antitrypsin and tumor necrosis factor alpha - 308 promoter polymorphism in Northeastern Mexico
Genetic Polymorphism of Tumor Necrosis Factor-Alpha, Interferon-Gamma and Interleukin-10 and Association With Risk of Mycobacterium Tuberculosis Infection - Gashaw Adane, Mulualem Lemma, Demeke Geremew, Tekeba Sisay, Mekibib Kassa Tessema, Debasu
Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis
PDF) 16* Glutathione S-transferase activity-genotype association with time and severity of Pseudomonas aeruginosa lung infection in cystic fibrosis children
PDF) Frequency of S and Z alleles for alpha-1-antitrypsin and tumor necrosis factor alpha - 308 promoter polymorphism in Northeastern Mexico
Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idiopathic urticaria
Association between TNF-α promoter –308 A/G polymorphism and rheumatoid arthritis: a meta-analysis
PDF) Association of Tumor Necrosis Factor Alpha 308 G/A Polymorphism with Asthma in Pakistani Population
Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis
Frontiers Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients
Schematic representation of the tumor necrosis factor-α (TNF-α) gene
The Tumor Necrosis Factor α (-308 A/G) Polymorphism Is Associated with Cystic Fibrosis in Mexican Patients
Author: Ali, Reham Ismail Ismail ./ Title: ASSOSIATION OF TUMOR NECROSIS FACTOR a-308 G/A POLYMORPHISM AND DEVELOPING DIABETIC NEPHROPATHY /
PDF) 16* Glutathione S-transferase activity-genotype association with time and severity of Pseudomonas aeruginosa lung infection in cystic fibrosis children
