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“Think about a brake when driving a car,” Chen explains. “If the brake is always engaged, you can’t drive. We found an siRNA that could remove the brake in this genetic pathway.”
Hearing Health Foundation (HHF) is the largest non-profit funder of hearing research. Since 1958, HHF has given away millions of dollars to hearing and balance research, including work that led to cochlear implant technology and now through the Hearing Restoration Project is working on a cure for hearing loss and tinnitus. HHF also publishes Hearing Health magazine, a free consumer resource on hearing loss and related technology, research, and products.
Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti, Stem Cell Research & Therapy
Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice — Hearing Health Foundation
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
Drug-Like Cocktail Used by Researchers to Regenerate Hair Cells for Hearing Loss in Preclinical Study
Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear
TRIM71 reactivation enhances the mitotic and hair cell–forming potential of cochlear supporting cells
Inner ear cells reprogrammed to regrow hair cell-like cells - RegMedNet
Frontiers Stem Cell-Based Therapies in Hearing Loss
Drug-Like Molecules Regenerate Hair Cell-Like Cells in Adult Mice
Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells - ScienceDirect
USC Stem Cell scientists find a simpler way to make sensory hearing cells - USC Stem Cell
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
Usher Syndrome Coalition on LinkedIn: FDA approves two gene therapies for sickle cell, bringing hope to…
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
